J Clin Pathol 25:1079-1082 doi:10.1136/jcp.25.12.1079
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Latex agglutination in the diagnosis of meningococcal meningitis

  1. W. P. J. Severin
  1. Department of Bacteriology, Municipal University of Amsterdam, Netherlands
  2. Laboratory of Hygiene, Municipal University of Amsterdam, Netherlands


      Group-specific polysaccharides of Neisseria meningitidis groups A and C have been demonstrated by means of a rapid, sensitive slide agglutination test with latex particles coated with antibodies. In this manner, the diagnosis can be made from the cerebrospinal fluid of patients with meningococcal meningitis caused by serogroups A or C even when the culture is negative. The method appears to be more sensitive than countercurrent immunoelectrophoresis and less elaborate.