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Aggregation of human platelets by commercial preparations of bovine and porcine antihaemophilic globulin
  1. C. D. Forbes,
  2. R. D. Barr,
  3. G. P. McNicol,
  4. A. S. Douglas1
  1. University Department of Medicine, Glasgow Royal Infirmary

    Abstract

    Infusion of commercial preparations of porcine and bovine antihaemophilic globulin into three haemophilic patients produced transient thrombocytopenia. This platelet-aggregating activity has been shown to be present in a wide range of animal plasmas and is related to the fibrinogen fraction. The mechanism of platelet aggregation by animal fibrinogen is discussed and some inhibitors of the reaction are described.

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    Footnotes

    • 1 Present address: Department of Medicine, University of Aberdeen. Foresterhill, Aberdeen AB9 2ZD.

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