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Serum α-macroglobulins in renal disease and preeclampsia
  1. C. H. W. Horne,
  2. J. D. Briggs,
  3. P. W. Howie,
  4. A. C. Kennedy
  1. University Department of Pathology, Royal and Western Infirmaries, Glasgow
  2. University Department of Medicine, Royal and Western Infirmaries, Glasgow
  3. University Department of Obstetrics and Gynaecology, Royal and Western Infirmaries, Glasgow

    Abstract

    The serum levels of α2-macroglobulin and pregnancy-associated globulin (another α-macroglobulin) have been measured by means of a radial immunodiffusion technique in (1) renal disease with and without proteinuria, (2) in age- and sex-matched controls, (3) in preeclampsia with and without proteinuria, and (4) in normal pregnant controls. There are significant increases in α2-macroglobulin and pregnancy-associated globulin in renal disease accompanied by proteinuria but normal levels are found in renal disease without proteinuria. Compared with normal pregnancy, α2-macroglobulin is significantly raised in preeclampsia with proteinuria but normal in preeclampsia without proteinuria. In contrast, serum pregnancy-associated globulin is significantly reduced in preeclampsia both with and without proteinuria when compared with normal pregnancy.

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