This study was undertaken to determine the interrelations between clinico-biochemical parameters and hepatic morphology in markedly obese patients. One hundred and sixty-six women and 52 men comprise this series. There was a statistically significant association of carbohydrate metabolism disturbance with increasing age and corpulence and, in women, with hyperuricaemia and morphological alterations of the liver. Menstrual irregularities also correlated well with hepatic morphology. The livers frequently exhibited steatosis, but other morphological changes were mild. Compared with women, men had higher triglyceride values, more severe hepatic involvement, and poorer correlation of carbohydrate disturbances with hepatic histology. The results indicate a central role of the impaired carbohydrate utilization in the biochemical and hepatic alterations of obesity.
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