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Indirect cutaneous immunofluorescence
  1. Thomas K. Burnham
  1. Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA

    II Clinical significance

    Abstract

    Sera of 532 patients with bullous diseases, connective tissue diseases and malignancies were tested for pemphigus epidermal intercellular fluorescence (ICF) and for the bullous pemphigoid `tubular' band by the indirect fluorescent antibody technique. Human normal skin cryostat sections were used.

    The band and ICF were seen primarily only in bullous pemphigoid and pemphigus respectively, Some indirect band and ICF-negative patients demonstrated positive direct results in involved skin. suggesting that direct tests should be performed in indirect negative patients clinically thought to have pemphigus or bullous pemphigoid.

    No close correlation was found between disease activity and positive or negative indirect tests in bullous pemphigoid and pemphigus. Steroids did not interfere with positive results of this diagnostically extremely valuable test.

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    II Clinical significance

    Footnotes

    • 1 Presented at the 92nd annual meeting of the American Dermatological Association, Dorado Beach, Puerto Rico, 14 April 1972.

      This investigation was supported in part by Public Health Service Research grant number 5RO1 CA 10999-03 IMB from the National Cancer Institute and in part by the Elizabeth and Charles Patterson Fund for Dermatology Research in lupus erythematosus.

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