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The fibrinolytic enzyme system in hypertension
  1. B. Bennett,
  2. D. Ogston,
  3. G. P. M. Crawford,
  4. A. S. Douglas
  1. Department of Medicine, University of Aberdeen

    Abstract

    Fibrinogen, fibrinogen-related antigen (FR-antigen), and components of the fibrinolytic enzyme system were measured in patients with essential hypertension, renal disease with and without hypertension, and normal subjects. Essential hypertension was associated with a decrease in plasminogen activator and an increase in FR-antigen. In renal disease these changes were accompanied by increases in plasminogen activation inhibitor, alpha2-macroglobulin, alpha1-antitrypsin, and fibrinogen.

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