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Enzymes involved in phenylalanine metabolism in the human foetus and child
  1. Anne McLean,
  2. Margaret J. Marwick,
  3. Barbara E. Clayton
  1. Department of Chemical Pathology, The Hospital for Sick Children, Great Ormond Street, London
  2. Institute of Child Health, Guilford Street, London

    Abstract

    The activities of phenylalanine p-hydroxylase, tyrosine: alpha-ketoglutarate and phenylalanine: pyruvate aminotransferases, and aromatic alpha-ketoacid reductase have been measured in liver biopsies obtained from children with a series of disorders other than phenylketonuria and from human foetuses aged 8·5 to 24 weeks. The importance of such a study in relation to the management of infants with hyperphenylalaninaemia and pregnant phenylketonuric women is discussed

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