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Cytochemical profile of B and T leukaemic lymphocytes with special reference to acute lymphoblastic leukaemia
  1. D. Catovsky,
  2. J. Galetto,
  3. A. Okos,
  4. E. Miliani,
  5. D. A. G. Galton
  1. MRC Leukaemia Unit, Royal Postgraduate Medical School, London

    Abstract

    The PAS and acid phosphatase reactions showed a different pattern of positivity in the cells of lymphoproliferative disorders according to their B or T cell nature. In B-cell leukaemias (chronic lymphocytic and prolymphocytic) a low proportion of lymphocytes gave a positive result with the acid phosphatase reaction, while the majority were PAS positive in granular form. In contrast, in the T-prolymphocytic and T-lymphoblastic leukaemias the acid phosphatase reaction was positive in the majority of cells, while the PAS reaction was only positive in a minority. The significance of these findings, particularly for the recognition of a distinct T-cell variant of acute lymphoblastic leukaemia, is discussed.

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