The initial clinical, pathological, and hormonal investigation of a patient with testicular feminization syndrome is described. Incubation of gonadal tissue with various radioactive substrates, together with the isolation and identification of the resulting metabolites, was demonstrated a high capacity to synthesize testosterone.
Two biosynthetic pathways were demonstrated, originating from progesterone and pregnenolone. These are essentially similar to those of the normal adult testes.
Low levels of activity were found in the phenolic fractions and no measurable production of oestrone, oestradiol, or oestriol was found.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.