Article Text

PDF

Assay of rifampicin in serum
  1. Jean M. Dickinson,
  2. V. R. Aber,
  3. B. W. Allen,
  4. G. A. Ellard,
  5. D. A. Mitchison
  1. Medical Research Council's Unit for Laboratory Studies of Tuberculosis, Royal Postgraduate Medical School, Ducane Road, London

    Abstract

    Two methods for the assay of rifampicin in serum are described. The first is a conventional plate diffusion method, measuring concentrations down to 0·02 μg/ml, and the second a chemical extraction followed by measurement of the inhibition of uptake of 14C-uridine by Staphylococcus aureus, which estimates in the range of 0·02 to 0·001 μg/ml. The methods were used to measure serum concentrations in man following doses of about 1050 mg and 75 mg rifampicin.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.