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The antigenic determinant of fibrin(ogen) measured with agglutination inhibition immunoassays
  1. Ayesha Molla1,
  2. Maria Benedetta Donati2,
  3. J. Vermylen
  1. Laboratory of Blood Coagulation, Medical Research Department, University of Leuven, Leuven, Belgium

    Abstract

    Agglutination inhibition immunoassays using antifibrinogen antiserum measure an antigenic determinant of fibrinogen which is located on the fragment D parts of this molecule. This antigenic determinant of fragment D, in contrast to others, does not form an immune precipitate with antifibrinogen antiserum. Upon very extensive hydrolysis by plasmin, this antigenic determinant has a reduced affinity for its antibody.

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    Footnotes

    • 1 Research fellow of the Katholieke Universiteit te Leuven.

    • 2 Research Fellow of the Katholieke Universiteit te Leuven 1972/73. Present address: Laboratory for Haemostasis and Thrombosis Research, Mario Negri Institute, V. Eritrea 62-20157 Milano, Italy.

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