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Studies on the diagnostic value of an immunofluorescence test for EB virus-specific IgM
  1. Joan M. B. Edwards,
  2. D. A. McSwiggan
  1. Virus Reference Laboratory, The Central Public Health Laboratory, Colindale, London
  2. Department of Microbiology, Central Middlesex Hospital, London

    Abstract

    A modification of the test for EB virus/IgM introduced by Schmitz and Scherer (1972) is described. It is simple and gives reproducible results.

    EB virus/IgM was demonstrated in all but one case of infectious mononucleosis and in students with minor illness shown to have acquired EB virus/IgG recently. Unlike the EB virus/IgG, the IgM disappears within a few months. Although the Paul-Bunnell-Davidsohn test is still the test of choice for the diagnosis of infectious mononucleosis, the EB virus/IgM test could be useful to establish a diagnosis of current or recent EB virus infection where the Paul-Bunnell-Davidsohn test was negative or equivocal.

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