The effect on the results obtained in surface counting investigations of using a dual detector counting system and multihole collimators has been investigated. The use of the additional detector results in smoother curves for the uptake of the radionuclide and the use of multihole collimators increases the discrimination of the counting system against the effects of radioactivity outside the region of interest. In a clinical trial to compare multihole collimation with conventional single hole collimation it was found that increased excess counts were obtained over the spleen with the multihole collimators in eight of ten cases.
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