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T-cell nature of leukaemic cells in a case of Sézary's syndrome with 'null-cell' features.
  1. L Lauriola,
  2. P Musiani,
  3. A Carbone,
  4. M Bartolini,
  5. P Cianciulli,
  6. M Piantelli

    Abstract

    alpha-naphthyl acetate esterase (ANAE) activity has been investigated in leukaemic cells from peripheral blood in a typical small-cell Sézary syndrome (SS) case in which cerebriform mononuclear cells failed to form E rosettes. The 'dot-like' ANAE positivity found in the majority of these neoplastic cells strongly supports a T-cell origin. In addition, a non-monocytic, non-B-cell nature of Sézary cells is indicated by the lack of Ia-like antigens. Finally, there is evidence of a distinct portion of Sézary cells simultaneously expressing ANAE activity and Fc IgM receptors.

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