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6-Thioguanine as a cause of toxic veno-occlusive disease of the liver
  1. MB Satti,
  2. K Weinbren,
  3. EC Gordon-Smith
  1. Department of Histopathology, Royal Postgraduate Medical School, London W12 0HS, UK
  2. Department of Surgery, Royal Postgraduate Medical School, London W12 0HS, UK
  3. Department of Haematology, Royal Postgraduate Medical School, London W12 0HS, UK

    Abstract

    Lesions of hepatic veno-occlusive disease were found in the needle biopsy specimen of one patient suffering from chronic granulocytic leukaemia and in the liver at necropsy of a second patient suffering from acute myeloid leukaemia. The treatment included administration of 6-thioguanine which was the only relevant compound used in the first patient and which was combined with cytosine arabinoside in the second patient.

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