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Use of monoclonal antibodies for the histopathological diagnosis of human malignancy
  1. KC Gatter*,
  2. Z Abdulaziz*,
  3. P Beverley,
  4. JRF Corvalan,
  5. C Ford,
  6. EB Lane§,
  7. M Mota*,
  8. JRG Nash*,
  9. K Pulford*,
  10. H Stein,
  11. J Taylor-Papadimitriou§,
  12. C Woodhouse,
  13. DY Mason*
  1. * Nuffield Department of Pathology, University of Oxford, John Radcliffe Hospital, Oxford
  2. ICRF Human Tumour Immunology Unit, University College Hospital, London
  3. Surgical Immunology Unit, Queen Elizabeth Hospital, Birmingham
  4. § Imperial Cancer Research Fund, Lincoln's Inn Fields, London
  5. Institute of Pathology, Christian Albrechts University, Kiel, West Germany
  6. Lilly Research Centre, Windlesham, Surrey

    Abstract

    This paper describes the use of a panel of seven monoclonal antibodies (selected so as to include reagents reactive with both epithelial and lymphoid cells) for distinguishing between anaplastic carcinoma and high grade lymphoma. Details are given of the immunohistological reactions of these antibodies against a wide range of both normal and malignant tissues and of a number of practical instances in which use of the antibody panel enabled a diagnosis to be made when routine histological examination had been inconclusive.

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