J Clin Pathol 36:1323-1331 doi:10.1136/jcp.36.12.1323
  • Research Article

Histomorphometry of bone.


This review of the histomorphometry of bone outlines methods of biopsy and processing of specimens in the laboratory, the basic principles of morphometry, and the measurements made in order to obtain estimates of the proportional volumes and surfaces occupied by different components of bone. Variability such as that between methods, observers and laboratories is discussed and a brief outline of automatic and semiautomatic methods of image analysis also given.