Article Text

PDF

Detection of immunoglobulins G and A on the cell membrane of hepatocytes from patients with alcoholic liver disease.
  1. A Trevisan,
  2. R Cavigli,
  3. R Meliconi,
  4. G F Stefanini,
  5. S Zotti,
  6. M Rugge,
  7. F Noventa,
  8. C Betterle,
  9. G Realdi

    Abstract

    The presence of immunoglobulins (Ig) G, A, and M and of complement fractions (C3-C4) on the liver cell surface was investigated by direct immunofluorescence in 40 patients with alcoholic liver disease. IgG was detected on the liver cell membrane with a linear staining pattern in 29 patients. The percentage of IgG-positive hepatocytes correlated with transaminase activities, independently of the histological findings. IgA was demonstrable with a coarse granular staining pattern in 11 of the 14 cases with established cirrhosis. The finding of IgG bound to the hepatocyte surface in patients with alcohol-induced liver damage suggests that alcohol could be responsible for antigenic modifications of hepatocyte membrane with consequent triggering of a humoral immune response.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.