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Splenic siderosis and parenteral iron dextran in maintenance haemodialysis patients.
  1. J A Murray,
  2. D N Slater,
  3. M A Parsons,
  4. M Fox,
  5. S Smith,
  6. M M Platts

    Abstract

    The histological features of 40 spleens surgically removed from maintenance haemodialysis patients are reported. Twenty-four of the 40 (60%) showed massive iron loading and a significant direct correlation was found between iron loading and the amount of intravenous iron dextran administered. Since parenteral iron dextran appears to be a major factor in causing iron overload in haemodialysis patients its use as a method of iron replacement in these patients would appear inappropriate.

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