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Evidence for monoclonal T lymphocyte proliferation in angioimmunoblastic lymphadenopathy.
  1. N T O'Connor,
  2. J A Crick,
  3. J S Wainscoat,
  4. K C Gatter,
  5. H Stein,
  6. B Falini,
  7. D Y Mason

    Abstract

    The arrangement of the T cell receptor and immunoglobulin genes was analysed in lymphoid tissue biopsy specimens from 25 cases of angioimmunoblastic lymphadenopathy. Nineteen cases showed a rearrangement of the gene coding for the beta chain of the T cell receptor, and in one case a clonal rearrangement of immunoglobulin genes was shown (in which the T cell receptor gene was in a germline configuration). These findings indicate that a monoclonal T cell proliferation is present in most cases of angioimmunoblastic lymphadenopathy, and they also correlate with the fact that some patients who present with this disorder subsequently develop a T cell lymphoma.

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