Article Text

PDF

Rheological effects of bed rest in sickle cell disease.
  1. A J Keidan,
  2. J Stuart
  1. Department of Haematology, Medical School, University of Birmingham.

    Abstract

    A serial rheological study in two patients with homozygous sickle cell disease whose leg ulcers healed as a consequence of bed rest showed an improvement in erythrocyte deformability (filterability) associated with evidence of decreased haemolysis and a fall in the number of irreversibly sickled cells. This rheological improvement may aid the healing of leg ulcers by increasing blood flow in the ulcer base. The effects of bed rest on the rheology of sickle cell disease should be taken into account in future studies of vaso-occlusive crisis.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.