Article Text

PDF

Cytogenic investigations in the assessment of response to treatment in neuroblastoma.
  1. N Bown,
  2. M M Reid,
  3. A D Pearson,
  4. E V Davison,
  5. A J Malcolm,
  6. A W Craft
  1. Department of Human Genetics, University of Newcastle upon Tyne.

    Abstract

    In a patient with stage IV disseminated neuroblastoma treated by chemotherapy extensive cytogenetic investigations were performed on the residual primary tumour and bone marrow immediately before myeloablative treatment and autologous marrow rescue. Two abnormal clones both showing lp+, a characteristic abnormality of neuroblastoma, were detected in cells from the residual primary tumour, providing direct evidence of persisting viable tumour. Such investigations should be a routine part of the assessment of response to treatment in patients with neuroblastoma, and could be extended to others in whom "second look" surgery is performed.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.