Serum amyloid A protein (SAA), apolipoprotein A-I (apoA-I), apolipoprotein B (apoB) concentrations, and creatine kinase (CK)-MB isoenzyme activity were serially measured in 10 patients during the course of acute myocardial infarction. Pronounced increases in SAA concentrations were observed in all patients during infarction. The highest SAA values were observed, on average, 67 hours after the onset of chest pain. After infarction both apoA-I and apoB concentrations decreased. The reduction in apoA-I concentration 67 to 72 hours after the onset of chest pain was (31%) (p less than 0.01) and the reduction in apoB concentration 55 to 60 hours after the onset of pain was (34%) (p less than 0.01). Negative correlations were found between the concentrations of SAA and apoproteins A-I and B; this inverse relation was stronger between SAA and apoB than between SAA and apo-AI.
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