Article Text

PDF

Parvovirus as a cause of hydrops fetalis: detection by in situ DNA hybridisation.
  1. H J Porter,
  2. T Y Khong,
  3. M F Evans,
  4. V T Chan,
  5. K A Fleming
  1. Nuffield Department of Pathology, University of Oxford, John Radcliffe Hospital.

    Abstract

    Lung tissue from 13 cases of unexplained non-immunological hydrops fetalis was examined by in situ hybridisation to detect parvovirus. Four specimens contained parvovirus DNA in cells in the blood vessel lumina and alveoli. Twenty six control cases were negative for parvovirus DNA. As there was no known epidemic of parvovirus infection during the study period, this suggests that parvovirus is a relatively common cause of non-immunological hydrops fetalis. In situ hybridisation may have a role in clinical medicine, particularly for retrospective investigations.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.