Article Text


C3 and C4 complement components and acute phase proteins in late pregnancy and parturition.
  1. I Z Kovar,
  2. P G Riches
  1. Department of Child Health, Charing Cross and Westminster Medical School, London.


    To determine whether changes in complement or acute phase proteins can predict onset of labour, complement components C3 and C4, alpha-1-antitrypsin, and alpha-1-acid glycoprotein were measured serially in the third trimester of pregnancy and throughout labour in 11 women. C-reactive protein (CRP) concentration, C3 conversion products, and factor B activation was studied in five pregnancies one week before delivery, during labour, and six weeks after delivery. C3, C4, and CRP concentrations were unchanged and there was no evidence of complement conversion, either immediately before or during labour, by the classical or alternative pathways. A wide variation among subjects but a small variation within subjects for all proteins assayed was noted. It is important to use serial rather than cross sectional biochemical data when determining normal physiological patterns in pregnancy. The proteins measured have no predictive value in the timing of the onset of normal labour.

    Statistics from

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.