Article Text


Circulating immune complexes after splenectomy.
  1. E A Donadi,
  2. I F Carvalho,
  3. R P Falcão
  1. Department of Clinical Medicine, School of Medicine, Ribeirão Preto, Brazil.


    Circulating immune complexes were evaluated in 25 patients (age range 10 to 46 years) who had undergone splenectomy for non-malignant conditions by studying a polyethylene glycol insoluble serum fraction. Although the extent of binding to Clq was within normal limits, these patients had increased concentrations of factor B in the immune complex serum fraction. These findings indicate that an unusual type of circulating immune complex may be detected after splenectomy, suggesting a possible role for the spleen in the removal of circulating immune complexes.

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