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Lack of C-erbB-2 protein expression in pulmonary carcinoid tumours.
  1. N Wilkinson,
  2. P S Hasleton,
  3. S Wilkes,
  4. A Quigley
  1. Department of Pathology, Wythenshawe Hospital, Manchester.

    Abstract

    To determine if amplification of the C-erb-B2 proto-oncogene could be correlated with prognosis in carcinoid tumours, 49 pulmonary carcinoid tumours (26 typical, 23 atypical) were examined using a polyclonal antibody to the C-terminal peptide of the C-erb-B2 protein sequence. No C-erb-B2 gene product could be shown: the demonstration of C-erb-B2 does not seem to help, therefore, in determining diagnosis or prognosis in pulmonary carcinoid tumours.

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