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Inhibition of urease activity but not growth of Helicobacter pylori by acetohydroxamic acid.
  1. J Goldie,
  2. S J Veldhuyzen van Zanten,
  3. S Jalali,
  4. H Richardson,
  5. R H Hunt
  1. Department of Laboratory Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada.


    The in vitro effects of acetohydroxamic acid (AHA), a potent urease inhibitor, were studied to determine the effect on the urease activity and growth of 38 strains of Helicobacter pylori. AHA in concentrations of 50-1000 mg/l had a noticeably reversible inhibitory effect on the urease activity of the organism but no effect on growth.

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