Article Text


Increased PIVKA-II concentrations in patients with cystic fibrosis.
  1. M de Montalembert,
  2. G Lenoir,
  3. A Saint-Raymond,
  4. J Rey,
  5. J J Lefrère
  1. Département de Pédiatrie, Hôpital des Enfants-Malades, Paris.


    Serum vitamin K concentrations and prothrombin induced by absence of vitamin K (PIVK-II) concentrations were assayed in 43 patients with cystic fibrosis. Twenty nine showed a normal PIVKA-II and vitamin K concentrations; 14 showed an increased PIVKA-II concentration, in one of whom serum vitamin K was decreased. Although their vitamin K concentrations were normal, some patients with cystic fibrosis still had an increased PIVKA-II. There was a significant correlation between PIVKA-II concentrations and the administration of antibiotics, a factor which has not previously been considered responsible for an increase in PIVKA-II.

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