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Parathyroid hormone related protein in hypercalcaemia of Hodgkin's disease.
  1. J Bolo-Deoku,
  2. S Basu,
  3. S Lakhani,
  4. F Dunne,
  5. W A Ratcliffe,
  6. M Clarke,
  7. J L Barron
  1. Department of Chemical Pathology & Metabolism, St Helier Hospital, Carshalton, Surrey.


    The role of parathyroid hormone related protein (PTHRP) as a humoral mediator of hypercalcaemia was investigated in a patient with lymphocyte depleted Hodgkin's disease during an episode of hypercalcaemia, using an immunohistochemical staining technique for PTHRP on the tumour tissue and an immunoradiometric (IRMA) assay for PTHRP1-86 on the patient's plasma. The plasma PTHRP was less than 0.23 pmol/l in the range found in normocalcaemic controls, and the immunohistochemical staining was not positive for protein. PTHRP did not have a role in the pathogenesis of hypercalcaemia in this patient.

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