Article Text

PDF

Parathyroid hormone related protein in hypercalcaemia of Hodgkin's disease.
  1. J Bolo-Deoku,
  2. S Basu,
  3. S Lakhani,
  4. F Dunne,
  5. W A Ratcliffe,
  6. M Clarke,
  7. J L Barron
  1. Department of Chemical Pathology & Metabolism, St Helier Hospital, Carshalton, Surrey.

    Abstract

    The role of parathyroid hormone related protein (PTHRP) as a humoral mediator of hypercalcaemia was investigated in a patient with lymphocyte depleted Hodgkin's disease during an episode of hypercalcaemia, using an immunohistochemical staining technique for PTHRP on the tumour tissue and an immunoradiometric (IRMA) assay for PTHRP1-86 on the patient's plasma. The plasma PTHRP was less than 0.23 pmol/l in the range found in normocalcaemic controls, and the immunohistochemical staining was not positive for protein. PTHRP did not have a role in the pathogenesis of hypercalcaemia in this patient.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Linked Articles