Article Text

PDF

Increase in severity of graft versus host disease by cytomegalovirus.
  1. A L McCarthy,
  2. J S Malik Peiris,
  3. C E Taylor,
  4. M A Green,
  5. L Sviland,
  6. A D Pearson,
  7. A J Malcolm
  1. Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne.

    Abstract

    An allogeneic transplant recipient developed severe graft versus host disease (GvHD) 48 days after transplantation that was concomitant with a cytomegalovirus (CMV) viraemia, from which she subsequently died. CMV infection was detected in blood by the polymerase chain reaction and later in tissue by immunohistochemical techniques. CMV should be considered in patients in whom GvHD does not respond to appropriate treatment, and this case suggests that herpes viruses may increase the severity of GvHD by synergistically enhancing the graft versus host reaction.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.