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Epstein-Barr virus in carcinoma of the vulva.
  1. A N Cheung,
  2. U S Khoo,
  3. K Y Kwong,
  4. G Srivastava,
  5. R J Collins
  1. Department of Pathology, University of Hong Kong.

    Abstract

    AIMS--To detect the presence of Epstein-Barr virus (EBV) in cases of vulval carcinoma in Chinese patients living in Hong Kong. METHODS--Formalin fixed, paraffin wax embedded blocks from eight cases of vulval carcinoma and six age matched controls of non-neoplastic vulval tissue were analysed for the presence of EBV DNA using the polymerase chain reaction (PCR). RESULTS--EBV DNA was detected in only one of the eight cases of vulval carcinoma cases while it was detected in four out of the six control cases. CONCLUSIONS--There is no demonstrable association between EBV and vulval carcinoma. Detection of EBV in non-neoplastic vulval epithelium highlights its ubiquitous presence in the lower female genital tract.

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