Article Text

PDF

Interobserver variation in the reporting of the histopathological grading of anal intraepithelial neoplasia.
  1. P S Carter,
  2. J P Sheffield,
  3. N Shepherd,
  4. D H Melcher,
  5. D Jenkins,
  6. P Ewings,
  7. I Talbot,
  8. J M Northover
  1. Colorectal Cancer Unit, St Mark's Hospital, London.

    Abstract

    AIM--To assess the consistency in the histological reporting of anal intraepithelial neoplasia (AIN) among experienced histopathologists. METHOD--One hundred anal biopsy specimens were retrieved from archival material at St Mark's Hospital, London and graded by five histopathologists according to criteria outlined by Fenger (six point scale, ranging from normal to invasive carcinoma). RESULTS--There was only moderate agreement among the pathologists, with unweighted k scores ranging from 0.09 to 0.48, and weighted k scores of 0.17 to 0.60. CONCLUSIONS--There is considerable interobserver variation in the reporting of AIN. A simplified system of grading may help to abolish this.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.