Article Text

PDF

An unusual epithelial pleomorphic giant cell tumour of the pancreas with osteoclast-type cells.
  1. A Martin,
  2. P Texier,
  3. J M Bahnini,
  4. J Diebold
  1. Service Central d'Anatomie et de Cytologie Pathologiques, Hôtel-Dieu, Paris, France.

    Abstract

    A case of giant cell tumour of the pancreas with a mixture of pleomorphic giant cells and osteoclast-like cells is described. This association is rare and its histogenesis has been debated. The presence of a small differentiated adenocarcinomatous area at the periphery of the tumour indicates an epithelial origin. Moreover, some pleomorphic cells were positive for keratin (KL1). The osteoclast-like cells strongly expressed CD68 (a marker of histiomonocytic lineage) and did not show proliferative activity. They probably correspond to an unusual reaction of the stroma. Their clinical importance in this type of tumour remains unknown.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.