J Clin Pathol 48:59-60 doi:10.1136/jcp.48.1.59
  • Research Article

Pathologist variation in reporting cervical borderline epithelial abnormalities and cervical intraepithelial neoplasia.

  1. T Creagh,
  2. J E Bridger,
  3. E Kupek,
  4. D E Fish,
  5. E Martin-Bates,
  6. M J Wilkins
  1. Department of Histopathology and Cytopathology, St Mary's Hospital, London.


      AIMS--To evaluate the interobserver variation in the diagnosis of cervical intraepithelial lesions, including the new category "borderline abnormalities of uncertain significance" (BAUS) which has not been tested before. METHODS--Biopsy specimens of 122 patients were reviewed by five histopathologists and the diagnoses subjected to kappa statistical analysis. RESULTS--There was poor interobserver agreement in all categories, particularly between BAUS and normal tissue. CONCLUSIONS--The current guidelines for the histological diagnosis of cervical intraepithelial neoplasia and BAUS are poorly reproducible.