Article Text


Acquired protein S deficiency in a patient with systemic lupus erythematosus causing central retinal vein thrombosis.
  1. H M Prince,
  2. P J Thurlow,
  3. R C Buchanan,
  4. K M Ibrahim,
  5. P J Neeson
  1. Department of Haematology, Austin Hospital, Heidelberg, Victoria, Australia.


    A 16 year old girl with systemic lupus erythematosus (SLE) developed the rare complication of central retinal vein occlusion. Although classically a disease of older patients, it has been recognised in association with SLE but only in the presence of the lupus anticoagulant or antiphospholipid antibodies. The thrombosis occurred when free protein S concentrations were transiently reduced and there was no family history or other known causes of reduced protein S concentrations. No other prothrombotic risk factors were present.

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