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Observer variability in histopathological reporting of non-small cell lung carcinoma on bronchial biopsy specimens.
  1. R A Burnett,
  2. S R Howatson,
  3. S Lang,
  4. F D Lee,
  5. A M Lessells,
  6. K M McLaren,
  7. E R Nairn,
  8. S Ogston,
  9. A J Robertson,
  10. J G Simpson,
  11. G D Smith,
  12. H B Tavadia,
  13. F Walker
  1. University of Glasgow Department of Pathology, Western Infirmary.

    Abstract

    AIMS: To evaluate the ability of histopathologists to sub-classify non-small cell lung carcinomas on bronchial biopsy material using the current World Health Organisation (WHO) classification. METHODS: Twelve histopathologists each reviewed 100 randomly selected bronchial biopsy specimens which had originally been reported as showing non-small cell lung carcinoma. For each case, two sections were circulated, one stained by haematoxylin and eosin and the other by a standard method for mucin (alcian blue/periodic acid Schiff). The participants were allowed to indicate their degree of confidence in their classification of each case. A standard proforma was completed and the results were analysed using kappa statistics. RESULTS: Where the participants were confident in their classification, they were actually quite good at sub-classifying the non-small cell carcinoma sections (kappa = 0.71, standard error = 0.058). Overall, however, the results were only fair (kappa = 0.39, standard error = 0.034). CONCLUSIONS: The majority of non-small cell lung carcinomas can be correctly categorised on adequate bronchial biopsy material. Where a confident diagnosis was made, both squamous carcinoma (kappa = 0.73) and adenocarcinoma (kappa = 0.83) were well recognised.

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