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Apolipoprotein E alleles in women with severe pre-eclampsia.
  1. B Nagy,
  2. J Rigó, Jr,
  3. L Fintor,
  4. I Karádi,
  5. T Tóth
  1. First Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest, Hungary. NABAL@NOI1.SOTE.HU

    Abstract

    This study investigated the frequency of apolipoprotein E (apoE) alleles among women with severe pre-eclampsia. The presence of the three most common apoE alleles (epsilon 2, epsilon 3, epsilon 4) was determined by polymerase chain reaction-restriction fragment length polymorphism in three groups of white women: non-pregnant healthy (n = 101), pregnant healthy (n = 52), and pregnant with a diagnosis of severe pre-eclampsia (n = 54). The frequency of apo epsilon 2 was highest among women with severe pre-eclampsia (16.6%) followed by non-pregnant women (12.9%), and those experiencing a healthy pregnancy (10.6%). The higher frequency of the apo epsilon 2 allele detected among women with severe pre-eclampsia suggests that apoE may play a role in the development of pre-eclampsia.

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