J Clin Pathol 53:655-665 doi:10.1136/jcp.53.9.655

Morphological identification of the patterns of prostatic intraepithelial neoplasia and their importance

  1. Rodolfo Montironi1,
  2. Roberta Mazzucchelli1,
  3. Ferran Algaba2,
  4. Antonio Lopez-Beltran3
  1. 1Institute of Pathological Anatomy and Histopathology, University of Ancona, Ospedale Regionale, I-60020 Torrette, Ancona, Italy
  2. 2Institute of Urology, Fundacio Puigvert, Hospital de la Santa Crue i Sant Pau, Universitat Autonoma de Barcelona, Cartagena 340-350, 08025 Barcelona, Spain
  3. 3Unit of Anatomic Pathology, Cordoba University Medical School, Avda. Menendez Pidal s/n, 14071 Cordoba, Spain
  1. Professor Montironi email: r.montironi{at}
  • Accepted 7 March 2000


High grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostatic carcinoma. PIN has a high predictive value as a marker for carcinoma, and its identification in biopsy specimens warrants repeat biopsy for concurrent or subsequent carcinoma. The only methods of detection are biopsy and transurethral resection; PIN does not greatly raise the concentration of serum prostate specific antigen (PSA) or its derivatives, does not induce a palpable mass, and cannot be detected by ultrasound. Androgen deprivation decreases the prevalence and extent of PIN, suggesting that this form of treatment might play a role in chemoprevention. Radiotherapy is also associated with a decreased incidence of PIN.