Should we screen for globin gene mutations in blood samples with mean corpuscular volume (MCV) greater than 80 fL in areas with a high prevalence of thalassaemia?

L C Chan; S K Ma; A Y Y Chan; S Y Ha; J S Waye; Y L Lau; D H K Chui

doi:10.1136/jcp.54.4.317

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Should we screen for globin gene mutations in blood samples with mean corpuscular volume (MCV) greater than 80 fL in areas with a high prevalence of thalassaemia?

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	Abstract	Full	Pdf
Mar 2001	5	3	1
Apr 2001	17	22	10
May 2001	4	15	3
Jun 2001	4	12	6
Jul 2001	4	20	1
Aug 2001	8	19	6
Sep 2001	3	27	2
Oct 2001	0	6	1
Nov 2001	1	6	5
Dec 2001	0	2	2
Jan 2002	3	16	5
Feb 2002	1	5	6
Mar 2002	2	12	2
Apr 2002	10	25	2
May 2002	4	9	5
Jun 2002	1	10	1
Jul 2002	3	13	5
Aug 2002	0	5	2
Sep 2002	1	4	1
Oct 2002	1	10	3
Nov 2002	4	11	6
Dec 2002	1	8	4
Jan 2003	1	7	4
Feb 2003	3	14	7
Mar 2003	2	11	6
Apr 2003	1	13	13
May 2003	9	7	7
Jun 2003	2	6	10
Jul 2003	6	72	0
Aug 2003	15	11	3
Sep 2003	12	16	2
Oct 2003	18	16	8
Nov 2003	11	26	2
Dec 2003	8	11	3
Jan 2004	10	47	3
Feb 2004	7	17	6
Mar 2004	13	19	13
Apr 2004	13	10	1
May 2004	38	36	2
Jun 2004	46	48	2
Jul 2004	48	73	20
Aug 2004	42	79	16
Sep 2004	31	69	3
Oct 2004	17	53	12
Nov 2004	12	51	8
Dec 2004	15	51	5
Jan 2005	12	66	2
Feb 2005	18	52	12
Mar 2005	17	44	9
Apr 2005	8	31	18
May 2005	7	46	21
Jun 2005	6	36	11
Jul 2005	9	30	2
Aug 2005	10	40	25
Sep 2005	10	47	8
Oct 2005	16	39	8
Nov 2005	22	41	13
Dec 2005	12	30	8
Jan 2006	13	31	5
Feb 2006	10	28	12
Mar 2006	8	31	3
Apr 2006	10	19	2
May 2006	5	23	7
Jun 2006	7	23	8
Jul 2006	5	21	7
Aug 2006	9	17	5
Sep 2006	15	18	9
Oct 2006	19	28	16
Nov 2006	11	56	13
Dec 2006	8	19	8
Jan 2007	5	10	4
Feb 2007	5	21	12
Mar 2007	12	29	21
Apr 2007	15	6	4
May 2007	13	6	4
Jun 2007	14	7	8
Jul 2007	11	10	2
Aug 2007	14	4	4
Sep 2007	9	3	1
Oct 2007	14	4	3
Nov 2007	11	3	4
Dec 2007	13	0	1
Jan 2008	21	1	1
Feb 2008	14	1	6
Mar 2008	16	5	3
Apr 2008	12	8	4
May 2008	9	3	5
Jun 2008	15	1	1
Jul 2008	26	2	6
Aug 2008	21	4	1
Sep 2008	48	4	4
Oct 2008	32	6	4
Nov 2008	8	5	5
Dec 2008	22	3	2
Jan 2009	18	4	7
Feb 2009	14	2	3
Mar 2009	27	2	2
Apr 2009	10	4	2
May 2009	12	3	3
Jun 2009	12	1	0
Jul 2009	20	3	1
Aug 2009	11	3	3
Sep 2009	17	2	2
Oct 2009	20	3	4
Nov 2009	12	5	0
Dec 2009	19	2	2
Jan 2010	11	3	3
Feb 2010	14	5	3
Mar 2010	36	1	2
Apr 2010	26	5	3
May 2010	20	1	3
Jun 2010	17	3	9
Jul 2010	26	4	6
Aug 2010	12	2	2
Sep 2010	15	5	4
Oct 2010	29	0	0
Nov 2010	21	5	3
Dec 2010	22	4	3
Jan 2011	20	5	3
Feb 2011	12	2	3
Mar 2011	14	3	6
Apr 2011	11	4	2
May 2011	14	2	3
Jun 2011	6	3	2
Jul 2011	12	0	1
Aug 2011	16	3	2
Sep 2011	25	4	3
Oct 2011	18	1	2
Nov 2011	18	7	2
Dec 2011	15	13	11
Jan 2012	13	6	7
Feb 2012	8	6	10
Mar 2012	11	10	6
Apr 2012	9	8	18
May 2012	13	13	26
Jun 2012	8	9	13
Jul 2012	9	7	16
Aug 2012	9	11	13
Sep 2012	13	13	34
Oct 2012	12	22	31
Nov 2012	15	14	32
Dec 2012	12	14	14
Jan 2013	25	18	13
Feb 2013	12	9	24
Mar 2013	12	14	19
Apr 2013	15	10	24
May 2013	29	19	28
Jun 2013	8	12	12
Jul 2013	12	5	10
Aug 2013	10	8	16
Sep 2013	11	7	14
Oct 2013	6	3	6
Nov 2013	17	9	16
Dec 2013	3	6	12
Jan 2014	8	10	14
Feb 2014	6	9	22
Mar 2014	12	12	11
Apr 2014	6	10	16
May 2014	18	9	19
Jun 2014	2	5	13
Jul 2014	27	9	6
Aug 2014	7	16	15
Sep 2014	10	13	19
Oct 2014	9	6	4
Nov 2014	6	0	2
Dec 2014	14	3	12
Jan 2015	6	7	8
Feb 2015	6	4	9
Mar 2015	13	4	19
Apr 2015	12	5	16
May 2015	8	8	7
Jun 2015	9	7	9
Jul 2015	5	7	3
Aug 2015	3	3	4
Sep 2015	16	10	9
Oct 2015	5	3	7
Nov 2015	15	4	5
Dec 2015	18	10	13
Jan 2016	20	5	8
Feb 2016	15	1	8
Mar 2016	7	3	13
Apr 2016	6	1	9
May 2016	13	5	10
Jun 2016	6	1	8
Jul 2016	10	3	13
Aug 2016	6	6	5
Sep 2016	15	6	1
Oct 2016	10	6	5
Nov 2016	10	1	2
Dec 2016	11	7	1
Jan 2017	12	6	5
Feb 2017	2	0	4
Mar 2017	1	10	0
Apr 2017	0	22	4
May 2017	2	28	3
Jun 2017	2	7	3
Jul 2017	9	9	1
Aug 2017	13	13	0
Sep 2017	19	17	2
Oct 2017	19	13	2
Nov 2017	65	65	3
Dec 2017	126	126	3
Jan 2018	108	106	2
Feb 2018	87	81	0
Mar 2018	75	65	3
Apr 2018	82	80	5
May 2018	39	39	4
Jun 2018	25	22	6
Jul 2018	32	32	10
Aug 2018	76	76	13
Sep 2018	58	58	18
Oct 2018	44	44	10
Nov 2018	58	58	14
Dec 2018	85	85	19
Jan 2019	62	59	18
Feb 2019	76	71	17
Mar 2019	89	85	16
Apr 2019	54	50	24
May 2019	49	48	15
Jun 2019	35	34	4
Jul 2019	37	37	7
Aug 2019	52	52	4
Sep 2019	43	41	6
Oct 2019	33	32	3
Nov 2019	24	24	6
Dec 2019	29	28	6
Jan 2020	31	28	2
Feb 2020	39	31	14
Mar 2020	21	19	3
Apr 2020	18	15	2
May 2020	23	22	6
Jun 2020	9	8	7
Jul 2020	17	15	3
Aug 2020	12	11	5
Sep 2020	15	14	4
Oct 2020	19	18	6
Nov 2020	20	18	4
Dec 2020	13	11	2
Jan 2021	22	18	4
Feb 2021	25	25	0
Mar 2021	12	11	4
Apr 2021	7	7	2
May 2021	14	13	7
Jun 2021	10	7	5
Jul 2021	12	11	7
Aug 2021	16	9	5
Sep 2021	14	13	4
Oct 2021	19	18	24
Nov 2021	22	20	13
Dec 2021	18	18	6
Jan 2022	15	13	9
Feb 2022	12	12	2
Mar 2022	23	20	7
Apr 2022	15	12	4
May 2022	25	25	6
Jun 2022	33	30	6
Jul 2022	22	21	0
Aug 2022	43	41	2
Sep 2022	27	24	16
Oct 2022	51	45	6
Nov 2022	17	12	1
Dec 2022	9	7	6
Jan 2023	20	19	5
Feb 2023	38	38	0
Mar 2023	8	8	4
Apr 2023	10	7	3
May 2023	5	3	6
Jun 2023	9	8	2
Jul 2023	33	30	8
Aug 2023	13	11	9
Sep 2023	13	12	3
Oct 2023	7	6	1
Nov 2023	12	12	1
Dec 2023	23	4	1
Jan 2024	27	1	0
Feb 2024	21	0	0
Mar 2024	98	3	2
Total	5067	5003	1955

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