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Fatal legionella pneumonia after fludarabine treatment in chronic lymphocytic leukaemia
  1. A Hendrick
  1. South Tyneside District Hospital, Harton Lane, South Shields, Tyne and Wear NE34 OPL, UK A.Hendrick@eem.sthct.northy.nhs.uk

    https://doi.org/10.1136/jcp.54.5.412-b

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      Treatment of chronic lymphocytic leukaemia (CLL) with nucleoside analogues may cause T cell dysfunction, thereby predisposing to opportunistic infections in addition to bacterial infections as a result of neutropenia and humoral immune dysfunction.1 The following case provides an example of fatal legionella pneumonia arising in these circumstances.

      A 62 year old male non-smoker had obtained a good partial response after completing four courses of fludarabine treatment for relapse of stage B CLL. He had been treated at diagnosis 2½12 …

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