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Correspondence
Fatal disseminated toxoplasmosis in a toxoplasma seropositive liver transplant recipient
  1. D Wendum,
  2. N Carbonell,
  3. M Svrcek,
  4. O Chazouilléres,
  5. J-F Fléjou
  1. Departments of Pathology and Hepatology, Hôpital Saint-Antoine, AP-HP, 184 Rue du Faubourg Saint-Antoine, 75571 Paris Cedex 12, France; dominique.wendum@sat.ap-hop-paris.fr

    https://doi.org/10.1136/jcp.55.8.637

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      Disseminated toxoplasmosis is a severe disease that occurs in immunocompromised patients but has been rarely reported after liver transplantation. We describe the first case of fatal disseminated toxoplasmosis in a toxoplasma seropositive liver transplant recipient with a documented lack of a rise in specific IgG.

      A 53 year old patient underwent liver transplantation because of decompensated alcoholic cirrhosis. The patient was treated with antithymocyte globulins and prednisolone. Tacrolimus was added and antithymocyte treatment stopped. Oral ganciclovir was given to prevent cytomegalovirus infection. On day 22, the patient developed fever with chills. Physical examination was normal and blood analysis revealed leucopenia (leucocytes, 700/mm3). Blood, urine, …

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