J Clin Pathol 57:77-78 doi:10.1136/jcp.57.1.77
  • Letters to JCP

Expression of DC-SIGN in human foreskin may facilitate sexual transmission of HIV

  1. E J Soilleux,
  2. N Coleman
  1. Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge CB2 2XY, UK
  1. Correspondence to:
 Dr E J Soilleux
 Medical Research Council Cancer Centre Unit, Hutchison/MRC Research Centre, Cambridge CB2 2XY UK;
  • Accepted 4 August 2003


This study demonstrates that the human immunodeficiency virus (HIV) binding C-type lectin DC-SIGN is coexpressed with CD4 and CCR5 on dendritic cells/macrophages in human foreskin. It is hypothesised that DC-SIGN may contribute to the sexual transmission of HIV in the foreskin, by enabling infection of permissive cells in cis and/or in trans.


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