You are here

Article Text

Article menu
Download PDFPDF
Letters to JCP
Expression of DC-SIGN in human foreskin may facilitate sexual transmission of HIV
  1. E J Soilleux,
  2. N Coleman
  1. Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge CB2 2XY, UK
  1. Correspondence to:
 Dr E J Soilleux
 Medical Research Council Cancer Centre Unit, Hutchison/MRC Research Centre, Cambridge CB2 2XY UK; ejs17cam.ac.uk

Abstract

This study demonstrates that the human immunodeficiency virus (HIV) binding C-type lectin DC-SIGN is coexpressed with CD4 and CCR5 on dendritic cells/macrophages in human foreskin. It is hypothesised that DC-SIGN may contribute to the sexual transmission of HIV in the foreskin, by enabling infection of permissive cells in cis and/or in trans.

  • human immunodeficiency virus
  • DC-SIGN
  • coreceptor
  • foreskin
  • transmission
  • DC-SIGN, dendritic cell specific intercellular cell adhesion molecule grabbing non-integrin
  • HIV, human immunodeficiency virus

https://doi.org/10.1136/jcp.57.1.77

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes