Expression of DC-SIGN in human foreskin may facilitate sexual transmission of HIV
- Correspondence to: Dr E J Soilleux Medical Research Council Cancer Centre Unit, Hutchison/MRC Research Centre, Cambridge CB2 2XY UK;
- Accepted 4 August 2003
This study demonstrates that the human immunodeficiency virus (HIV) binding C-type lectin DC-SIGN is coexpressed with CD4 and CCR5 on dendritic cells/macrophages in human foreskin. It is hypothesised that DC-SIGN may contribute to the sexual transmission of HIV in the foreskin, by enabling infection of permissive cells in cis and/or in trans.
- DC-SIGN, dendritic cell specific intercellular cell adhesion molecule grabbing non-integrin
- HIV, human immunodeficiency virus