Statistics from Altmetric.com
Young age and symptoms should be included in predictive algorithms of urethral infection; they are better predictors of urethral infection in men than numbers of urethral polymorphonuclear leucocytes (PMNs), an evaluation study of non-gonococcal urethritis (NGU) has disclosed.
The evaluation substituted the ligase chain reaction for PMN count as the diagnostic test for C trachomatis and calculated sensitivity and specificity of the cut offs in PMN count in stained urethral smears as well as the likelihood of PMN count, symptoms, and age predicting C trachomatis urethritis. Over 300 men being screened for sexually transmitted infection at one clinic over four weeks were tested; none had gonococcal urethritis.
Age below 30 versus 40 and above increased likelihood of infection with C trachomatis 13-fold; PMN count, at ⩾20 per high power field (hpf), sixfold and 5-9 per hpf, threefold; and dysuria threefold. However, the sensitivity of PMN count at ⩾5 per hpf was just 63% and specificity 77%. Over a third of the men with C trachomatis by ligase chain reaction had PMN counts <5 per hpf—too many to justify the accepted diagnostic cut off at ⩾5. The proportion of men with NGU on a stained urethral smear was 26%, and it was associated with C trachomatis in 8%, according to the ligase chain reaction.
With nucleic acid amplification becoming available for C trachomatis it made sense to re-evaluate apparent relations between urethral infection and clinical picture, PMN count, and routinely available information like age and symptoms.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.