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High molecular weight caldesmon positive stromal cells in the capsule of hepatocellular carcinomas
  1. H Nakayama1,
  2. H Enzan2,
  3. M Yamamoto2,
  4. E Miyazaki2,
  5. W Yasui1
  1. 1Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8551, Japan
  2. 2Department of Pathology, Kochi Medical School, Kohasu, Nankoku, Kochi 783-8505, Japan
  1. Correspondence to:
 Dr H Nakayama
 Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8551, Japan; nakayamhhiroshima-u.ac.jp

Abstract

Aims: To investigate the smooth muscle nature of the stromal cells in the capsule of hepatocellular carcinomas.

Methods: Immunohistochemical analysis using monoclonal antibody to high molecular weight caldesmon (HCD), a highly specific marker for smooth muscle cells, was performed in 33 encapsulated hepatocellular carcinomas and adjacent hepatic tissues.

Results: HCD positive stromal cells were detected in the capsule of 21 of the 33 hepatocellular carcinomas examined.

Conclusions: The capsule of hepatocellular carcinomas contains smooth muscle cells.

  • HBV/HCV, hepatitis B/C virus
  • HCD, high molecular weight caldesmon
  • high molecular weight caldesmon
  • capsule
  • stroma
  • hepatocellular carcinoma

https://doi.org/10.1136/jcp.2004.016279

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