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  • Synchronous ileal and colonic adenocarcinomas associated with Crohn’s disease: report of a case with a focus on genetic alterations and carcinogenesis

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Case report
Synchronous ileal and colonic adenocarcinomas associated with Crohn’s disease: report of a case with a focus on genetic alterations and carcinogenesis
  1. B Baisse1,
  2. C Fontolliet1,
  3. Y S Bian1,
  4. H Vuilleumier2,
  5. J Benhattar1
  1. 1Institute of Pathology, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland
  2. 2Surgical Department, Centre Hospitalier Universitaire Vaudois
  1. Correspondence to:
 Dr J Benhattar
 Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH-1011 Lausanne, Switzerland; jean.benhattarchuv.hospvd.ch

Abstract

Patients with Crohn’s disease have an increased risk of developing intestinal tumours. However, the carcinogenic mechanisms remain poorly understood. To address this question, this report describes an unusual case of Crohn’s disease complicated by synchronous small intestinal and colonic adenocarcinomas. Genetic events in both the tumours and their adjacent mucosae were evaluated and the tumorigenesis of these cancers is discussed.

  • APC, adenomatous polyposis coli
  • DCC, deleted in colon cancer
  • MSI, microsatellite instability
  • Crohn’s disease
  • intestinal adenocarcinoma
  • genetic alterations
  • mutation
  • K-ras mutation

https://doi.org/10.1136/jcp.2003.014811

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