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Splenic marginal zone lymphoma with predominant red pulp involvement lacking p53 overexpression
  1. S-S Chuang1,
  2. C-F Li2,
  3. D Lu3,
  4. T-C Tsai4,
  5. C-J Tsao5
  1. 1Department of Pathology, Chi-Mei Medical Centre, Tainan; Taipei Medical University, Taipei, Taiwan
  2. 2Department of Pathology, Chi-Mei Medical Centre, Tainan, Taiwan
  3. 3Department of Pathology, Liou-ying Chi-Mei Hospital, Tainan, Taiwan
  4. 4Department of Surgery, Liou-ying Chi-Mei Hospital, Tainan, Taiwan
  5. 5Department of Internal Medicine, Liou-ying Chi-Mei Hospital, Tainan, Taiwan
  1. Correspondence to:
    S-S Chuang
    Department of Pathology, Chi-Mei Medical Center, 901 Chung-Hwa Road, Yung-Kang City, Tainan County 710, Taiwan; cmh5301{at}mail.chimei.org.tw

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Splenic marginal zone lymphoma (SMZL) is defined in the World Health Organization (WHO) classification as a B cell lymphoma comprising small lymphocytes that surround and replace the splenic white pulp and merge with a peripheral (marginal) zone of larger cells, leading to a biphasic zonal pattern. The tumour involves the spleen, splenic hilar lymph node, bone marrow and often, peripheral blood. Recently, Mollejo et al1 proposed a putative diffuse variant of SMZL with predominantly red-pulp involvement, absence of follicular replacement and a monomorphous population of tumour cells resembling marginal zone B cells, with scattered nucleolated blast cells. They found high p53 expression in all four patients, with p53 gene mutation in two.

Here, we report a case similar to that reported by Mollejo et al, without p53 overexpression. A 34-year-old woman presented …

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