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Intrapatellar tendon lipoma with chondro-osseous differentiation: detection of HMGA2-LPP fusion gene transcript
  1. Y Matsui1,
  2. T Hasegawa2,
  3. T Kubo1,
  4. T Goto1,
  5. K Yukata1,
  6. K Endo1,
  7. Y Bando3,
  8. N Yasui1
  1. 1Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
  2. 2Division of Pathology, National Cancer Research Institute, Tokyo, Japan
  3. 3Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
  1. Correspondence to:
    Dr Yoshito Matsui
    Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan; ymatsui{at}sb4.so-net.ne.jp

Abstract

A 54 year old man developed an unusual lipoma in the patellar tendon, consisting of a fibro-adipose component and a chondro-osseous component. The fibro-adipose component contained mature adipocytes, lipoblasts, and fibroblasts; the chondro-osseous component showed typical endochondral bone formation. Molecular analysis showed that the identical HMGA2-LPP fusion transcript—characteristic of lipoma, parosteal lipoma, and pulmonary chondroid hamartoma—was detectable in the both components.

  • lipoma
  • chromosomal translocation
  • RT-PCR
  • endochondral bone formation

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