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High grade prostatic intraepithelial neoplasia with squamous differentiation
  1. M Melissari1,
  2. A Lopez Beltran2,
  3. R Mazzucchelli3,
  4. E Froio1,
  5. D G Bostwick4,
  6. R Montironi3
  1. 1Department of Pathology and Medicine of Laboratory, Section of Pathological Anatomy and Histology, University of Parma, Parma, Italy
  2. 2Department of Pathology, Reina Sofia University Hospital and Faculty of Medicine, Cordoba, Spain
  3. 3Section of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, School of Medicine, Ancona, Italy
  4. 4Bostwick Laboratories, Glen Allen, Virginia, USA
  1. Correspondence to:
    Professor Rodolfo Montironi
    Section of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona), School of Medicine, Umberto I Hospital, Via Conca 71, I−60020 Torrette, Ancona, Italy; r.montironi{at}univpm.it

Abstract

An unusual variant of prostatic intraepithelial neoplasia with prominent and extensive squamous differentiation is described. The lesion was identified in the transition zone of a 79 year old man with a three year history of increasing urinary obstructive symptoms and a clinical diagnosis of benign prostatic hyperplasia who underwent simple prostatectomy. Two years after surgery, prostatic biopsies showed atrophy and mild chronic inflammation, with no evidence of malignancy. This unusual intraepithelial lesion seems not to have been described before and may represent a new variant of high grade prostatic intraepithelial neoplasia (HGPIN) with squamous differentiation.

  • BPH, benign prostatic hyperplasia
  • HGPIN, high grade prostatic intraepithelial neoplasia
  • ISH, in situ hybridisation
  • PIN, prostatic intraepithelial neoplasia
  • high grade prostatic intraepithelial neoplasia
  • squamous differentiation
  • prostate cancer
  • benign prostatic hyperplasia

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