Article Text

PDF
Hypoplasia and neuronal immaturity of the hypoglossal nucleus in sudden infant death
  1. G Ottaviani,
  2. L Matturri,
  3. R Mingrone,
  4. A M Lavezzi
  1. Institute of Pathology, “Lino Rossi” Research Centre for the study and prevention of unexpected perinatal death and SIDS, University of Milan, Milan, Italy
  1. Correspondence to:
 Dr Giulia Ottaviani
 Institute of Pathology, University of Milan, Via della Commenda 19, 20122 Milan, Italy; giulia.ottaviani{at}unimi.it

Abstract

Objective: To report the case of five month old female baby with a history of episodes of gastro-oesophageal reflux and pneumonia. Her sudden death offered a unique insight into the possible role of delayed neuronal maturation and hypoplasia of the hypoglossal nucleus in representing a likely morphological substrate of sudden death.

Methods: Morphometric analysis was carried out with an Image-Pro Plus Image analyser (Media Cybernetics) on both sides of the brain stem.

Results: Hypoplasia and neuronal immaturity of the hypoglossal nucleus were demonstrated, accompanied by hypoplasia of the arcuate nucleus.

Conclusions: Much attention should be paid to the possible role of the hypoglossal nucleus in determining a lethal outcome in infancy through impairment of deglutition and subsequent recurrent episodes of pneumonia, and as a necropsy finding.

  • SIDS, sudden infant death syndrome
  • hypoglossal nucleus hypoplasia
  • hypoglossal nucleus neuronal immaturity
  • aspiration pneumonia
  • passive smoking
  • borderline SIDS

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.